Root 66 Cannabis

Root 66 Dispensary in St Louis

3737 S Grand Blvd
St Louis, MO 63118

Hours of Operation:

Tues – Sat 10am – 6pm

Payment Methods:

Cash & Debit Only

DISPENSARY - Open

Root 66 Dispensary is a state-licensed dispensary located in St. Louis, Missouri, offering a wide selection of high-quality medical and recreational cannabis products to meet customers needs.

Menu Products: This cannabis store offers a variety of medical and recreational cannabis products, including flower, edibles, concentrates, tinctures, and topicals, as well as accessories like vaporizers and rolling papers.

Adult Use Recreational: Root 66 offers recreational cannabis products to those over 21 years of age. Whether you’re looking to relax after a long day or enhance your creative pursuits, they have something for everyone.

Medical Marijuana: For those with a valid medical marijuana card, the staff will work with you to determine the best products for your specific needs and help you understand the different strains, dosages, and consumption methods available. See if you qualify today!

Root 66 Cannabis Store In St Louis

What People Are Saying

Root 66 S Grand
4.6
Based on 248 reviews
Eric M.
Eric M.
1689961152
Unfortunately i was not allow the joy of "service"Who cant be excited about quality cannabis? Well my experience was not so bad, but very uncomfortable.Let me explain.Excited to make my first purchase at a dispensary I chose root 66. After a great conversation with my sales rep. I happily approached to pay. Gosh darn they dont take credit cards only cash or debit. It was 30 minutes till close and i couldnt make it back so begrudgingly i went home.No cannabis.So today, cash in hand i eagerly return, same great experience. I even had the gaurd laughing because i told her that the glass breath stank. We laugh i went through the door and my same rep from the other day greeted me. .we had such a great experience the first time, he called me by name😊Im so ready to get my 300.00 order. Then a very attractive woman came into the store. In a very whisper like voice. I told my rep. "That's a great looking woman " She neither heard or probably noticed me at all she was in and out before you knew it. No harm no foul. Correct? No!I was told."This isnt a club she didnt come in here for that."I said oh i would never approach her im 60. She was my daughter's age maybe 25 i dont know but, she wasnt aware of our personal conversation..See if i were loud , disruptive even flirtatious i could understand setting an environment where customers feel safe but this wasnt that at all.I was told, "You're gonna get into trouble." I asked "how what did i do?"I said "im talking to you she doesnt even know im here"I was shown the door🤷‍♂️So i went to Another dispensary. Your loss
Caitlin B.
Caitlin B.
1688854336
Alyssa really knows her stuff. Made me feel very comfortable with her knowledge about the product she was selling, I'll definitely be back here because of her!
TheGreatGoobah
TheGreatGoobah
1686781512
When this shop opened they had a good selection and range of prices on different flower. In the last several months their supply has been extremely limited (sometimes only 5-6 different types of bud in store) and prices have been approaching double what i get at other area dispensaries - this price discrepancy is readily apparent in the price of 1/8ths ($50-60 for most options here) while i can find similar quality and THC content at other local dispensaries for $25-30 per 8th or even less. Cant shop here while its this expensive.
King C.
King C.
1686667913
Went to this dispensary recently and it was a pleasant experience. The staff was super friendly, the inside was really nice,and I was in and out. The budtender was cool and gave me his opinions on the flavors he's tried. Definitely will return to this place.
Bobbie P.
Bobbie P.
1680320581
It sounds corny BUT Root 66 IS your fast track to get what you want/need! Guys..... This process was so flawless & smooth.... So impressed!! I pre ordered... SO convenient, set my time for pick up, they let me know when my order was ready. I was in/out literally 5-7 mins!! Good vibes here... You can feel it. Awesome job Root 66!!!! Y'all nailed it.
Nicole B.
Nicole B.
1680005244
Nice place to visit and very friendly employees. Would have been 5 stars BUT buyer beware. This was my first purchase and I ordered the 1906 Plant based tablets. On the packaging and removable label it states there are 30 tablets. There were only 20!!! The tablets were $40 and I didn't get what I paid for. HAVE THE CASHIER CHECK YOUR ITEMS BEFORE YOU PAY!! Then check them again. You will not get a refund but 50% off another item. Though I believe they should have given a partial refund.
Ryan W.
Ryan W.
1677530859
Great customer service, and I believe they have the best prices compared to quality than other places. Like Proper has good quality products but ridiculously high prices, and at the other end of the spectrum is Nature Med, so bad the lowest prices anywhere, but the quality is just so so. I would recommend this place first to anyone who is looking for the best prices. And they get you in and out faster than any other place I've been to.
Nicole B.
Nicole B.
1677286607
Nice place to visit and very friendly employees. Would have been 5 stars BUT buyer beware. This was my first purchase and I ordered the 1906 Plant based tablets. On the packaging and removable label it states there are 30 tablets. There were only 20!!! The tablets were $40 and I didn't get what I paid for. CHECK YOUR ITEMS BEFORE YOU LEAVE!!
Hector S.
Hector S.
1676646152
Great staff, competent security (indoors), safe environment & they do their best to keep the showroom spacious. Best prices in STL for recreational & supremely potent smalls / concentrates & flower.The parking lot is torturous, have someone wait in your car as security rarely comes outside & I've seen 2 hit and runs from exiting customers in my past 3 visits.
Stephanie K.
Stephanie K.
1675343492
Very knowledgeable, helpful and efficient.The bud tenders will never steer you wrong.You tell them your desired results... (mine is being able to sleep all night without waking up in pain.)They find exactly what you need without upselling you.That's one thing they are fantastic about... finding the best deals!The best pharmacy I've ever been to. With the friendliest people.
Robert R.
Robert R.
1671224817
Great place to go wonderful. People that work there most friendly and have knowledge on everything from the flower to the terpin that taste get. I love this place
Langen and A.
Langen and A.
1671129296
Everyone at the south grand store is SO kind and helpful. In particular, Eric and Chris, really helped me out the other day. Not just because of the high quality products either, I was having a bad day and it was like Chris could tell and just made sure I had someone friendly to talk to for a few minutes. It really turned my day around.Definitely love this place.
Jake Y.
Jake Y.
1669400390
Awesome place best prices in town lowekey underated super helpful group of people been in many times and was my first they printed my medical card for me they always are helpful usually always get some freebies love the sales cant beat them headed back up there today for the hundredth time happy smoking hit your local Root 66 up
Tami
Tami
1662138841
I have genuinely never had a bad experience in here. The staff are some of the best around. They take the time to explain and talk about the products so it doesn’t feel as impersonal as some of the other places.As much as I adore everything who works there, I do need to give a couple of extra kudos. Kris and Eric are my dudes. They’ve never lead me astray and have helped introduce me to things I never know I needed to know.Thank you so much staff at Root 66.You are amazing ✌🏻🤟🏻
Alyse G.
Alyse G.
1659736794
Hello, my name is Alyse and I adore Root66 on Grand. As soon as you walk in, there is Bella there with a friendly hello but always keeps it professional. After you get buzzed through, a bud tender is there to assist. Shannon was helpful and resourceful as she helped me find some edibles and cannabis strains to help with health issues. She send me to the cash let once I’m done selecting and Kris was there to help ring me out with such a uplifting optimistic attitude. I enjoy my experience every time I come here.
Kris R.
Kris R.
1659391411
Great staff. Good product selection and prices. Good deals too. Shout out to Shannon Cori Kris & Isaac for being so knowledgeable and kind.
Gabriel H.
Gabriel H.
1659209876
Been coming here pretty frequently since I got my med card in March.Literally always a great experience, very friendly staff and they'll actually give you recommendations based on your taste that'll save you money.Have to give a shout out to Corey, Shannon and Isaac for the great experience and vibes so far. Keep it up guys
Rachel N.
Rachel N.
1658533221
Best place ever. Super east to order online and the best customer service from the staff. Shannon, Isaac, Bella. Always come see these guys for your after affair needs.
J S
J S
1658493528
First trip to a dispensary and I'm so happy that I chose to stop in at Root 66 on S Grand! I wasn't sure what to expect and was nervous but the facility was welcoming and the staff was super friendly. Special shout out to Corey for being the MOST helpful and thoroughly answering my questions! 10 out of 10 experience, honestly. This is a gem and I hope they thrive!
Charles V.
Charles V.
1658457742
My first dispensary purchase! Very friendly staff! I had pre ordered online and they were ready for me when I arrived. Got a t-shirt and some stickers as well! I am 51 and can tell you I have been waiting for this day since I was a teenager. Highly recommend!
O.C. W.
O.C. W.
1658372101
Love this place! Had a great experience, was helped by Shannon and got exactly what I needed!
Rudie R.
Rudie R.
1658360391
Friendly and informative staff, quick and easy pick up, will be back! Shannon in particular is amazing!
Mappy B.
Mappy B.
1655589969
My first time at a dispensary and it was fantastic. The people there were super friendly and didn't pressure for us to buy anything. They explained products, shared their personal experience with the products, and shared feedback other costumers gave them. As someone who is still learning the benefits of 1:1 products with CBD, CBC, CBG, etc, the employees were extremely helpful. And the guy at the front window reminded us of Argyle in Stranger Things 4 so that was awesome. Highly recommend!
Lauren W.
Lauren W.
1651591812
The people here are super chill with great customer service. They are knowledgable and will help you find what you're looking for.
Megan M.
Megan M.
1650919649
They don't even care about their own employees, so they definitely don't care about you.
Carol E.
Carol E.
1650842238
Great shop with great deals. My original dispensary was bought out by Proper, not my favorite flower. So I’ve been coming here. Super nice staff and product.
Xamine B.
Xamine B.
1647194936
Great staff.. love that I can pop in and pop out with ease of service. The staff greets me by name which will always make you feel like your appreciated.. products have been getting better and better and better.. continue the great work
Harold C.
Harold C.
1643572087
The people that work here are top notch. Prices are best in the Lou.
Poki C.
Poki C.
1643353674
Work on getting a staff that actually knows cannabis, Idk how many bud tenders I’ve talked to already, they only hire people in sales and not knowing about cannabis, They rather upsale you then help you follow your nose for the right terps that fit you, from now on I will only talk too bud tenders that know what THC stands for, and remember to ask every bud tender what’s the difference from CBG and THC, CBD is too easy, Give them a challenge and see who actually knows cannabis, I had bud tenders look right at there manager as soon as I asked them a question or they give a quick answer to just make a quick sale, So many noobs, They just have a confused face the whole time
Mary A.
Mary A.
1641742950
Prices are pretty much the same at all these type of stores. I personally like greenlight way better, I think Root 66 needs to do a better loyalty program as much as the products costs... Can get the same stuff from your local neighbors for way less but being as the prices seem to be pretty set and average they need to upgrade their loyalty program! I want to give it a 3.5 not a 4 and mainly bc the staff at this location don't seem as educated as staff at other shops. In my opinion I would drive past this store for a greenlight store based on them having a bigger selection of products, sales and again probably the best loyalty program and the staff at any green light store I go to seem very educated on the products and help find the right product opposed to the feeling of just being a customer which is the feeling you get at the root. (Based strictly based on my own personal experiences)
J
J
1639761945
I want to thank the staff for all their help today. Jake, Em, Prince, Mickey and Bobby all were very professional and understanding. I was glad they made the experience very easy and simple, they even laminated my card for me, so I don't have to try to get it off my phone each time. They explained how my allotment worked and how and when it turns over. Being a first time customer and getting a few goodies was great as well. Thank you for making my first time easy!Update: Shout out to Micah and Devin for their recent recommendations!
Brett G.
Brett G.
1639671453
Best customer service and prices in St Louis. Don't pass this gas!
Brian B.
Brian B.
1637022140
was mainly going out of way to this location for the delta 8 they had good product and good price . Bring them back!! get in and out quickly with online orders
D. W.
D. W.
1635831040
Friendly service. They carry the capsules so now I don't have to cough to get relief. Competitive pricing. Nicely done Root 66.
Hazmat The C.
Hazmat The C.
1633048421
Root 66 is a clean, charming and professionally run environment. The budtenders are helpful and knowledgable. While the inventory has less choice, they are building a steady client base (including myself). Everyone is helpful and personable. A good place to try and I would recommend the Ostara vape line.
L H
L H
1628886634
Very good products. Neatly organized and very clean. Thanks guys
J
J
1628361335
I want to thank the staff for all their help today. Jake, Em, Price, Mickey and Bobby all were very professional and understanding. I was glad they made the experience very easy and simple, they even laminated my card for me, so I don't have to try to get it off my phone each time. They explained how my allotment worked and how and when it turns over. Being a first time customer and getting a few goodies was great as well. Thank you for making my first time easy!
mike L.
mike L.
1626409275
Everybody was super helpful and knowledge.In particular Manda explained how to use bonus points, took her time with me to make sureI understood that, and how the usage/monthly Missouri allotment works:)Real professionals!!!I'll be returning.
Jake
Jake
1625094793
Extremely easy to enter, and get started thanks to the friendly and helpful staff. Gentleman who assisted me was very knowledgeable, non judgmental and helpful in recommending strains and answering all my questions about varieties and equipment. Such a relief!
Paula H.
Paula H.
1623180807
My first time at Root 66 did not disappoint. The flower is top notch, the gummies are really, really good, and the drinks are tasty. Wonderful service from Bobbie and Matt and a warm and welcoming environment in general. I will be back. Also thanks for printing and laminating my new card.
Alison C
Alison C
1623121263
Great flower selection and incredibly warm and welcoming staff, not to mention extremely knowledgeable!! Bonus that they print and laminate your patient ID card!! Will definitely be back soon to try more products:)
James H.
James H.
1622856781
Nice lil south side gem very clean first dispensary in the midewest that I've been to that actually displays they're products. They also have an Extremely knowledgeable and helpful staff
K G.
K G.
1622658050
Only Pay With Cash, Not Your Card. 3 stars missing for limited selection and overcharging my card. The cashier said my total was $67 and change, but that he would have to run my card for $70 even and I would get the difference back in cash. No big deal and there was what looked like a tip jar on the counter and staff had been friendly, so I left the cash there. When I checked my balance, I realized that they actually charged me OVER $70 plus a $1 convenience fee that they neglected to tell me about. As welcoming as they were, I won't be returning.UPDATE: They still didn't own up to it after seeing this. To clarify, your staff charged me $73.50 (which is NOT an increment of 5) plus the fee for a total of $74.50. My credit union never charges fees for using other ATMs, one of the reasons I stay loyal to them. I was only given $2.50 back in cash. So you actually stole about $5 from me, not including the tip I left. Thankfully, there's still another $2k in that account so it isn't worth going back there for $5. It's just the principle. Don't steal from your customers and then lie about it. This is exactly why I wish I could post photos and screenshots on here. So now it's 1 star. Word of mouth also works 😉
K G.
K G.
1622571144
Only Pay With Cash, Not Your Card. 3 stars missing for limited selection and overcharging my card. The cashier said my total was $67 and change, but that he would have to run my card for $70 even and I would get the difference back in cash. No big deal and there was what looked like a tip jar on the counter and staff had been friendly, so I left the cash there. When I checked my balance, I realized that they actually charged me over $70 plus a $1 convenience fee that they neglected to tell me about. As welcoming as they were, I won't be returning.
DragonLord72 T.
DragonLord72 T.
1621357329
There were four employees in the store but only three were giving outstanding service. He was a tall somewhat skinny white guy outside of that the other staff were excellent. A talk with management is needed with him on good energy.
Ali C.
Ali C.
1620173698
The staff there is amazing! I was a bundle of nerves before walking in and within minutes I was calm and comfortable. Mickey was super helpful, very friendly. I'm definitely going back
Marian C.
Marian C.
1619221078
Root66 has such an amazing vibe. I love the fact that they offer to not only print out your Patient card, but they will also laminate it for you on the spot! What a wonderful first impression. Mickey is a juggernaut of joy and knows their products. I'm excited to see what this store can really do!
Cicely D.
Cicely D.
1618527182
Fast and friendly and the product is top of the line
Tehran R.
Tehran R.
1618174065
Great place to get medical
Justin M.
Justin M.
1617705015
Cannabis is better than opiates and opioids
Ed F.
Ed F.
1617052572
Really nice staff, very knowledgeable. The selection is still a bit limited but I expected that. Nice store, welcome to St Louis!
Robert B.
Robert B.
1616189469
I've been a few times now and the staff was always professional and friendly. The store is clean, modern and surprisingly big on the inside. The products are on par with CO or CA but they charge $70 to $80 per eighth, in other medical states you can get the same quality eighth for $25 to $35, I know it's new to MO but this is supposed to be medical not REC. Prices.
Tyler Z.
Tyler Z.
1616045663
The products here are insanely marked up. You can get the same flower for 55-60 dollars an eight from every store but this one. Don't believe their "we don't get wholesale prices" excuses. Their grower(Illicit) has publicly stated they give everyone the same price. Drive out to Ellisville or Greenlight in Ferguson. Don't get ripped off.
JEFFREY F.
JEFFREY F.
1615948524
Good location
Adam C.
Adam C.
1615856396
Overpriced
jerry W.
jerry W.
1615678012
Today was my first visit and I was very happy with my visit and I will be going pretty regularly now, so I give them 5 stars!!
Liam O.
Liam O.
1615046752
The very best!
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