Root 66 Cannabis Dispensary

Root 66 Cannabis Dispensary in St Louis

6660 Manchester Ave
St Louis, MO 63139

Hours of Operation:


Payment Methods:

Cash & Debit Only

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Root 66 Cannabis Dispensary in St Louis located at 6660 Manchester Ave is now open to help MO marijuana card holders get access and shop for medical marijuana products.

Root 66 menu products are available for MMJ Patients near St Louis diagnosed with a Qualifying Condition from a Certified MMJ Doctor.

Root 66 Cannabis St Louis Dispensary Menu

Any interactions with the live menu below, such as, but not limited to, product searches or order placing, take place directly with the menu provider. has no access to any personal data or transactional information when you are interacting with the menu.

What People Are Saying

Justine Rodebaugh
Justine R.
17:44 16 Jul 21
This morning was my first visit to this dispensary.Not only is it less than 2 miles from my house. The entire staff is so friendly and accommodating and really took time to help me. I really appreciate the great customer service & awesome product selection. I highly recommend this dispensary. I’ll definitely be back!!read more
Ginni Bauer
Ginni B.
12:45 15 Jul 21
The staff is extremely knowledgeable and so super friendly! They are always ready to answer any questions you may have. Their selection has grown a lot the past month or so and they have just about anything you could need. My favorite dispensary by far!read more
David Hults
David H.
17:19 02 Jul 21
Thoughful and knowledgeable staff are really awesome at this new dispensary. Order online for best immediate selection easy pickup, shop in store and find all the new things cannabis is made into!read more
Noah Saunders
Noah S.
13:27 23 Jun 21
Knowledgeable staff cool clean collective atmosphere, best selection I’ve seen in the city from mid grade to high grade and the super coool kind friendly staff. Great execution I look forward to my next experience!P.s. the Bubba was “Pure Beskar” haha they’ll get it, cheers!read more
Steenz Stewart
Steenz S.
22:13 08 Jun 21
Very knowledgeable and kind staff! Very easy to show your card, get your goods, and be on your way. I hope they get even more variety in the future, but until then it's got what I need!read more
Timothy Simms
Timothy S.
21:23 25 May 21
Very nice staff and the place is always clean. I will continue to be a customer.
Little Rosamond Hoyle
Little Rosamond H.
19:23 11 May 21
While they do not have a huge selection yet, it is quite diverse. The staff were very helpful and friendly. They never made me feel stupid about not knowing things and I came out satisfied with my more
joe kesler
joe K.
15:58 04 May 21
You can only use this facility if you download a PDF to their website. A printout or photo is not enough. Who needs an extra hoop to jump through?read more
Ed Foy
Ed F.
21:55 29 Apr 21
A great staff, very knowledgeable and helpfull. A great experience
adam tullock
adam T.
06:23 25 Apr 21
Pretty chill place.
Christine Todd
Christine T.
15:35 23 Apr 21
Wonderful facility with knowledgeable employees.
Oliver Fend
Oliver F.
22:04 09 Apr 21
Turned right around when they told me their cheapest 1/8th was 70 bucks. I don't know how they live with themselves.Imagine saying your cheapest 1/8th is 70 bucks with a straight more
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